Wednesday, 25 August 2010

Crabsallover Liver Function tests - Serum alanine aminotransferase & Serum total bilirubin

Crabsallover Tested July 2010 (Twin Oaks)
Alanine transaminase (ALT)
  •  Serum alanine aminotransferase: Crabsallover: 25 iu/L (range ex.Twin Oaks : 0-35 iu/L) aka Alanine transaminase (ALT)
    • NOT PRESENT: but if were...elevated levels of ALT suggest viral hepatitis, congestive heart failure, liver damage, bile duct problems, infectious mononucleosis, or myopathy. 
    • NOT PRESENT: but if were.. elevated ALT levels due to liver-cell damage can be distinguished from biliary duct problems by measuring alkaline phosphatase. Myopathy-related ALT levels can be ruled out by measuring creatine kinase. 
  • Range via Reference ranges for blood 0.15-1 ukat/L
no levels guidance given

  • Serum total bilirubin: Crabsallover: 18 umol/L and 20 umol/L on 3/11/11, range (ex. Twin Oaks): 0-17 umol/L 

    •  5.1-17umol/L and some sources 1.5-25umol/L total bilirubin (Reference range for blood tests)
    • Bilirubin is the yellow breakdown product of normal heme catabolism found in hemoglobin. Bilirubin is excreted in urine and is responsible for the yellow color of bruises & urine.
    • High levels of bilirubin in the blood may be caused by:
      • infections eg infected gallbladder, or cholecystitis. 
      • inherited diseases eg Gilbert's syndrome (affects how liver processes bilirubin)
      • Diseases that cause liver damage eg hepatitis, cirrhosis, or mononucleosis. 
      • Diseases that cause blockage of the bile ducts eg gallstones or cancer of pancreas. 
      • Rapid destruction of red blood cells eg sickle cell disease 
    • To elucidate causes of jaundice or increased bilirubin liver function tests (eg alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase), blood film examination (hemolysis, etc.) or evidence of infective hepatitis (e.g., hepatitis A, B, C, delta, E, etc.)
    • high Bilirubin levels can result from red blood cell breakdown or liver disease. Two different chemical forms of bilirubin—direct (or conjugated) and indirect (or unconjugated) bilirubin are tested. If the direct bilirubin is high there may be some kind of blockage of the liver or bile duct, perhaps due to gallstones, hepatitis, trauma, a drug reaction, or long-term alcohol abuse. If the indirect bilirubin is increased, haemolysis (undesirable breakdown of red blood cells) may be the cause.
Seek further medical opinion - 18 umol/L bilirubin is outside the range (Twin Oaks): 0-17 umol/L

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