Wednesday, 24 April 2013

Does Aspirin prevent Breast Cancer?

reposted from: | FASEB Abstract by Gargi Maity, Archana De Snigdha, Banerjee Amlan Das and Sushanta Banerjee - Kansas City
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Taking a low dose of aspirin every day could have the potential to prevent breast cancer or stop it in its tracks.

That was the news over the weekend from the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston, where a team of researchers from the Veterans Affairs Medical Center in Kansas City and the University of Kansas Medical Center presented evidence demonstrating the effects of aspirin against two types of breast cancer.

One of them, so-called “triple negative” cancer, is the most aggressive type of breast cancer and also the most dangerous because it often doesn’t respond to conventional therapies.

FASEB Abstract
Aspirin, a classical non-steroidal anti-inflammatory drug (NSAID) is widely used to reduce pains and fever. Epidemiological and experimental studies suggested that Aspirin use reduces the risk of different cancers including breast cancer and may be used as a chemopreventive agent against breast cancer and other carcinogenesis. These studies have raised the tempting possibility that Aspirin could serve as a preventive medicine for breast cancer. However lack of in-depth knowledge of the mechanism of action of Aspirin reshapes the debate of risk and benefit of Aspirin in prevention of breast cancer. Our aim is to investigate effects of Aspirin on pathophysiological events like epithelial to mesenchymal transition (EMT), migration, stemness of cell in breast cancer cells. Our studies using in vitro and in vivo tumor xenograft model show a strong beneficial effects of Aspirin in prevention of breast carcinogenesis. We find Aspirin not only prevents breast tumor cell proliferation in vitro and tumor growth in xenograft mouse model, it also significantly inhibits other pathophysiological events in breast cancer such as EMT, cell migration as well as reprogramming of stemness in breast cancer cells. Collectively our studies suggest that intake of an ASPIRIN a day might offer additional avenues for breast cancer prevention and treatment.

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