|The gut-brain axis: |
Emerging evidence in health and disease
"Instead of conceptualizing Major Depressive Disorder (MDD) as an emotional disorder, Turhan Canli suggests to reconceptualize it as some form of an infectious disease."
"I suggest that some unknown pathogen(s) could play a causal role, and that the immune response is secondary to the infection; interventions that only target the immune response may bring symptom relief but would not address the root cause of the illness."Inflammatory markers of infectious disease in depressive patients have been found (Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R)).
"I think it would be worthwhile to conduct large-scale studies of carefully characterized depressed patients and healthy controls, using gold-standard clinical and infectious disease-related study protocols, as have already been developed for bacteria and viruses. Such efforts, if successful, would represent the ‘end of the beginning’, as any such discovery would represent the first step toward developing a vaccination for major depression."NHS Choices report findings of a peer-reviewed journal. More....
Links To The Headlines
Could depression be an INFECTIOUS DISEASE? Condition is caused by parasites, bacteria or virus and could be prevented with a jab, expert claims. Mail Online, November 27 2014
What If We're Wrong About Depression? New York Times, November 26 2014
Links To Science
Canli T. Reconceptualizing major depressive disorder as an infectious disease. Biology of Mood and Anxiety Disorders. Published online October 21 2014