Fine Tuning body weight

reposted from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2582659

I googled: fine tuning body weight, because I'm curious to know how the body fine tunes body weight maintenance. As the article states "Although it is true that weight gain occurs when food intake exceeds energy expenditure, it is important to note that even a 1% mismatch between the two can lead to a substantial weight gain after only a few years." 1% of 2000 calories/day = 20cals/day x 365 days = 7300 cals per year. 3500 cals excess results in one pound increase. So 7300 cals excess = 2 pounds increase per year = 20 pounds over 10 years.

Could there be a fine-tuning role for brain-derived adipokines in the regulation of bodyweight and prevention of obesity? by Russell E. Brown

Abstract: "The body appears to balance energy metabolism via an endogenous lipostatic loop in which adipose stores send hormonal signals (e.g. adipokines such as leptin) to the hypothalamus in order to reduce appetite and increase energy expenditure. However, the brain is also a novel site of expression of many of these adipokine genes. This led to the hypothesis that hypothalamic-derived adipokines might also be involved in bodyweight regulation by exerting some effect on the control of appetite or hypothalamic function." ... Although adipokines secreted by adipose tissue appear to the main regulator of lipostatic loop, this review shows that the fine tuning that is required to maintain a stable bodyweight by this system might be accomplished by hypothalamic-derived adipokines. Perturbations in this central adipokine system could lead to alterations in normal hypothalamic function which leads to unintended weight gain."

Crabsallover Summary: Adipokines derived from the brain (hypothalamus) might control the reduction of appetite and increase energy expenditure, in addition to Adipokines derived from fat (adipose) tissues.