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"Moreover, in monkeys (and by extension, humans) some benefits of dietary restriction, such as low IGF-I levels, may decrease cancer risk, but also increase the risk of osteoporotic fractures 35. Thus, it might be necessary to reduce IGF-I signalling during early adulthood to prevent cancer, but increase it at older ages to prevent non-cancerous diseases 36."
"Moreover, in monkeys (and by extension, humans) some benefits of dietary restriction, such as low IGF-I levels, may decrease cancer risk, but also increase the risk of osteoporotic fractures 35. Thus, it might be necessary to reduce IGF-I signalling during early adulthood to prevent cancer, but increase it at older ages to prevent non-cancerous diseases 36."
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