Tuesday, 13 March 2012

Aspirin which emits Hydrogen Sulphide & Nitric Oxide reduces cancer


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Kashfi et al coupled oxynitroxy and aryl sulphur moieties to aspirin to give NOSH1 which had, compared to aspirin; improved inflammation properties, reduced gastrointestinal bleeding and increased aspirins potency to prevent and reduce colon and other cancers.

Fig.1: Chris Street, OU S827, March 2012
Fig.2: Chris Street, OU S827, March 2012 


CGS1) New Scientist, 10 March 2012 (accessed 15th March 2012)
CGS2) Kodela, R., Chattopadhyay, M., Kashfi, K., ‘NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals’, ACS Med. Chem. Lett., 2012, 3, pp. 257-262
CGS3) in press: Chattopadhyay, M., Kodela, R.,, Olson, K. R., Kashfi, K., 'NOSH–aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model', Biochem. Biophys. Res. Commun., 2012, doi:10.1016/j.bbrc.2012.02.051 

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