Wednesday, 21 March 2012

Effect of daily aspirin on risk of cancer metastasis by Peter Rothwell

Further research by Peter Rothwell - digging around in "old archives in dusty basements" indicates:-
  • aspirin can reduce cancer growth or metastasis 
  • aspirin works to prevent metastasis in the same way it reduces heart attacks and strokes. Aspirin works by platelet inhibition. There are far fewer platelets roaming the body assisting cancer to metastasis 
  • aspirin might help in treatment of some cancers
  • stopping of aspirin after diagnosis of cancer could be detrimental
  • treat 10,000 cancer patients with aspirin for cost of one treated with Herceptin


Primary Research
  • Rothwell P et al, Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trial, Lancet (2012) DOI:10.1016/S0140-6736(12)60209-8
  • Rothwell, P et al, Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials, Lancet (2012) DOI:10.1016/S0140-6736(11)61720-0
  • Algra A & Rothwell P, Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials, Lancet Oncology (2012) DOI:10.1016/S1470-2045(12)70112-2 
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More Peter Rothwell Aspirin research blogged since 2010 by crabsallover.

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